In addition to her parents, she was predeceased by her husband in 2008 her brothers, Earle, Rowan, Daniel Sr., Neil Jr., Linwood and Abbott Stewart and her sisters, Waneta Butler and Patricia MacEwen. She is also survived by one sister-in-law, Ellen Stewart of Orrington as well as several nieces and nephews.
She is survived by her two daughters, Priscilla Kimball and her husband, John, of Holden and Paula Demers and her husband, Dave, of Springvale five grandchildren, Sarah Agarwal and husband, Asheesh, Rachel Moreau and husband, Gary, Emily Demers and husband, Shane Hughes, Jeanne Watts and husband, Ryan, and Katie Scanlon and husband, Tom and seven great-grandchildren, Neil, Colby, Lincoln, Calvin, Kelcey, Caleb and Jesse. She enjoyed countless hours in her flower garden, long car rides throughout Maine, traveling and camping. Anita worked in the home raising her daughters she was a devoted wife, mother, grandmother, great-grandmother, sister, aunt and friend. 18, 1946, she married her beloved husband Paul F. She graduated from Brewer High School in 1939. 7, 1918, in Orrington, the daughter of Neil and Flora (Livingston) Stewart. Robbins, 92, died peacefully Friday, July 15, 2011. These results indicate that simple TCR substitution variants that enhance T cell function can be identified by rapid transfection and assay techniques, providing the means for generating potent Ag complex-specific TCR genes for use in the study of T cell interactions and in T cell adoptive immunotherapy.BANGOR and BUCKSPORT - Anita S. Separate experiments on two distinct TCRs that recognize the MART-1 27-35 (AAGIGILTV) peptide/HLA-A*02 Ag complex characterized single amino acid substitutions in both TCRs that enhanced CD4(+) T cell Ag-specific reactivity.
Within this group of improved TCRs, a dual substitution in the 1G4 TCR CDR3alpha chain was identified that enhanced Ag-specific reactivity in gene-modified CD4(+) and CD8(+) T cells. The screening of a panel of variants of the 1G4 TCR, that recognizes a peptide corresponding to amino acid residues 157-165 of the human cancer testis Ag NY-ESO-1 (SLLMWITQC) in the context of the HLA-A*02 class I allele, resulted in the identification of single and dual CDR3alpha and CDR2beta amino acid substitutions that dramatically enhanced the specific recognition of NY-ESO-1(+)/HLA-A*02(+) tumor cell lines by TCR gene-modified CD4(+) T cells. Substitutions that enhance the reactivity of TCR gene-modified T cells to the cognate Ag complex were identified using a rapid RNA-based transfection system. Single and dual amino acid substitution variants were generated in the TCR CDRs of three TCRs that recognize tumor-associated Ags.
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